Tale of cautionneed for frozen section biopsy in the. Schwartz who studied a group of asianindian women living in. Oral submucous fibrosis rajendran r j oral maxillofac pathol. Oral submucous fibrosis osmf is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in india and southeast asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro. Proposed clinical definition for oral submucous fibrosis ncbi. The disease is rare in north america, and most cases seen in migrants from south east asia or india. Oral submucous fibrosis osmf, oral fibrosis introduction oral submucous fibrosis is a chronic disease of insidious onset featuring the deposition of fibrous tissue in the submucous layer of the palate, fauces, cheek, lips, pharynx and esophagus. Oral submucous fibrosis osmf is one such disease, which is an insidious, chronic, complex, crippling, debilitating, irreversible, persistent progressive, scarring, potentially malignant and collagen metabolic disorder. O ral submucous fibrosis is a chronic, insidious disease affecting the oral cavity and sometimes pharynx. Taking lycopene for 23 months might help these people open their mouth. Oral submucous fibrosis osf is a medical condition that affects the mouth by causing inflammation of the mucous tissues and the formation of fibrous growths on the walls of the mouth.
Know all about the disease, including its possible causes, symptoms, diagnosis and treatment options. Oral submucous fibrosis an overview sciencedirect topics. Rajendran1 oral submucous fibrosis osmf, a precancerous condition of the oral cavity, has been studied by a numberofworkers in the field. Betel nut and pan are freely available in the united kingdom, and in a city such as leicester, one might expect to find 3000 cases of oral submucosal fibrosis. Osf can lead to squamous cell carcinoma, a risk that is further increased by concomitant tobacco consumption. Some people with this condition cant open their mouth as wide as normal. Oral submucous fibrosis medical specialties clinical. Classification system for oral submucous fibrosis chandramani bhagvan more, swati gupta, jigar joshi, saurabh n varma abstract oral submucous fibrosis osmf is a potentially malignant disorder pmd and crippling condition of oral mucosa.
The treatment of patients with oral submucous fibrosis depends on the degree of clinical involvement. Oral submucous fibrosis causes, symptoms, treatment and. Osmf is a form of pathological fibrosis which is characterized by progressive inability to open the mouth due to loss of elasticity and development. Pindborg in 1966 as an insidious, chronic disease that affects any part of the oral cavity and sometimes the pharynx. A sharp increase in the incidence of oral submucous fibrosis was noted after pan parag came onto the market, and the incidence continues to increase. Compared to traditional betel quid, gutkha chewing tends to begin at a younger age and has a shorter time to the development of disease, so cases of oral submucous fibrosis have been seen as young as 11 years of age. Oral submucous fibrosis is a precancerous condition, commonly seen in people from the indian subcontinent.
Etiopathogenesis and management of oral submucous fibrosis. Role of microrna profiling in oral submucous fibrosis. Oral submucous fibrosis definition of oral submucous. Restricted mouth opening in a patient with oral submucous fibrosis osf. It is very common in southeast asia but has started to spread to europe and north america. The disease is rare in north america, and most cases seen in.
Etiopathogenesis and management of oral submucous fibrosis seema basoya department of oral medicine and radiology, s. Oral submucous fibrosis osmf is a chronic disorder seen only in persons who chew betel areca catechu nuts, pan masala or gutkha and is characterized by tightening of the buccal, and sometimes palatal and lingual mucosae, causing trismus. Oral submucous fibrosis osmf is a chronic progressive, scarring disease affecting oral, oropharyngeal, and sometimes the esophageal mucosa. Healthy normal patients served as the control group. Oral submucous fibrosis osmf has traditionally been described as a chronic, insidious, scarring disease of the oral cavity, often with involvement of the pharynx and the upper esophagus. Oral submucous fibrosis osf is a premalignant condition caused by betel chewing. Oral submucous fibrosis is it time to modify the definition. New definition for leukoplakia and reclassification.
Pdf proposed clinical definition for oral submucous fibrosis. A total of 96 patients with oral submucous fibrosis have received four regimens of treatmentlocal dexamethasone, local hyaluronidase, local combination of dexamethasone and hyaluronidase, and local placental extract. The condition was aptly described by sirsat and pindborg as an insidious chronic disease affecting any part of the oral cavity and sometimes pharynx. Over the years, different authors have classified this condition based on clinical, histopathological or functional aspects. Although occasionally preceded andor associated with vesicle formation, is. Definition and clinical manifestations of the disease are summarized in table 1. Oral submucous fibrosis is a chronic, complex, premalignant 1% transformation risk condition. Aug 08, 2019 oral submucous fibrosis osf is a debilitating, potentially cancerous oral condition, caused primarily by chewing areca nut and its mixtures, as demonstrated by numerous epidemiological studies and other corroborative evidence. Malignant transformation of oral submucous fibrosis in taiwan.
Malignant transformation of oral submucous fibrosis in. The available epidemiological data showed a clearcut geographical and ethnic predisposition, which suggested that certain. Tale of cautionneed for frozen section biopsy in the management of oral sub mucous fibrosis author. Oral submucous fibrosis osmf is a chronic disease of oral mucosa characterized by inflammation and progressive fibrosis followed by stiffening of an otherwise yielding mucosa resulting in difficulty in opening the. Per chandramani more and naman rao 2019 clinical definition a debilitating. Scribd is the worlds largest social reading and publishing site.
A common complaint is a progressive stiffness of the cheeks, which inhibits the ability to open the mouth. Oral submucous fibrosis medical specialties clinical medicine. Oral submucous fibrosis osmf as a disease remains an enigma to the clinicians due to elusive pathogenesis and less well defined classification systems. Surgical fibrolysis and skin grafts in the management of. Ahmed department of oral and maxillofacial surgery dr. Jul 01, 20 oral submucous fibrosis osmf is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in india and southeast asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro. Oral submucous fibrosis free download as powerpoint presentation. The habit is prevalent in south asian populations but has been recognized nowadays also in europe and north america. Oral submucous fibrosis osmf was defined by pindborg and sirsat as an insidious, chronic disease affecting any part of the oral cav ity and sometimes the pharynx, although occasionally preceded by andor associated with vesicle formation, it is always associated with. Incidence rate of oral submucous fibrosis osmf and its. Dental college, hospital and research institute, india introduction oral submucous fibrosis was first described by schwartz in 1952 among five. Surgical fibrolysis and skin grafts in the management of oral. To evaluate the incidence of oral squamous cell carcinoma concomitant with oral sub mucous fibrosis in central india and to correlate precipitating factors associated with oral submucous fibrosis and oral squamous cell carcinoma.
Worldwide, estimates of oral submucous fibrosis indicate that 2. Oral dysplasias and squamous cell carcinomas are complications of oral submucous fibrosis. The who definition for an oral precancerous condition a generalized pathological state of the oral mucosa associated with a significantly increased risk of. Oral submucous fibrosis treatment peoplebeatingcancer. Autogenous buccal fat pad in the treatment of oral submucous fibrosis. The use of buccal fat pad in the treatment of oral submucous. Oral submucous fibrosis is a disease due to a chronic, insidious change in fibroelasticity, characterized by burning sensation in the oral cavity, blanching, and stiffening of the oral mucosa and oropharynx leading to trismus and inability to open the mouth. Aim of this study was to evaluate the split skin graft held in place with a polyethylene stent for the treatment of oral submucous fibrosis. Oral submucous fibrosis osmf is a potentially malignant disorder which was described by schwartz in 1952 as atropica idiopathica mucosae oris and later by jens j. Oral submucous fibrosis osmf has traditionally been described as a chronic, insidious, scarring disease of the oral cavity, often with. Fifteen prospective patients diagnosed clinically with.
This paper also aims to study the incidence of oral squamous cell carcinoma arising secondary to untreated oral submucous fibrosis. For a painful mouth disease that reduces ones ability to open the mouth oral submucous fibrosis. Oral submucous fibrosis is a chronic, complex, premalignant 1% transformation risk condition of the oral cavity, characterized by juxtaepithelial inflammatory reaction and progressive fibrosis of the submucosal tissues the lamina propria and deeper connective tissues. Although occasionally preceded by, or associated with, the formation of vesicles, it is always. A retrospective study, int oral health, 7, 2015, 8285. Oral submucous fibrosis, pre malignant free download as powerpoint presentation. Oral submucous fibrosis osmf etiology epidemiological data and intervention studies suggest that areca nut is the main aetiological factor for osf pindbor. If the disease is detected at a very early stage, cessation of the habit is sufficient. Oral submucous fibrosis osmf has traditionally been described as a chronic.
Atrophic squamous epithelium with collagenisation of the sub epithelial tissue with scanty inflammatory cells. Oral submucous fibrosis, pre malignant cancer inflammation. Gupta s, reddy mvr, harinath bc, role of oxidative stress and antioxidants in aetiopathogenesis and management of oral submucous fibrosis, ind j clinbiochem, 19, 2004, 8. Oral submucous fibrosis osmf is an insidious, chronic, complex, crippling, debilitating, irreversible, progressive, scarring, potentially malignant and collagen metabolic disorder, induced by a known carcinogen areca nut.
Oral submucous fibrosis can be seen at any age except for young children. Contents introduction definition epidemiology nomenclature classification etiopathogenesis clinical features histopathology differential diagnosis special investigations malignant potential treatment and management. In severe cases of osmf, through examination of oral oral submucous fibrosis is not a premalignant lesion syed s. Oral sub mucous fibrosis is a crippling disease of mouth with high malignant potential that has high prevalence rate in india and south east asia. New definition for leukoplakia and reclassification of leukoplakias as separated disease entities. Oral submucous fibrosis osf is a chronic, progressive, scarring disease, that predominantly affects the people of southeast asian origin. A study using ol lesion showed that curcumin reduced the size of a lesion by 10% in the treated 62 patients. Sri sankara dental college, kerala university, india abstract amongst the list of premalignant conditions, oral submucous fibrosis osmf forms one.
Oral submucous fibrosis osmf is a disease of unknown etiology. Oral submucous fibrosis also occurs in other parts of asia and the pacific islands. Asian migrants in european countries also present with trismus due to fibrosis of the submucosal tissue in the oral cavity. The characteristic feature of oral submucous fibrosis is reduced movement and depapillation of the tongue, blanching and leathery texture of oral mucosa and progressive reduction of mouth opening. Oral submucous fibrosis osmf is a chronic, insidious, irreversible disease characterized mainly by two symptoms, burning sensation in the mouth while eating spicy hot food in early stages of the disease and trismus in the late stages of the disease. Uses, side effects, interactions, dosage, and warning.
Oral submucous fibrosis osmf is an insidious, chronic, complex, crippling, debilitating, irreversible, progressive, scarring, potentially. A link between scleroderma and oral submucous fibrosis has also been suspected on the basis of similarity of histological characteristics tsai et al, 1999. Advanced oral submucous fibrosis with dysplastic changes. Oral submucous fibrosis osf is an extremely discomforting oral condition that is marked by the development of painful lesions inside the mouth that refuse to go away on their own. It causes progressive immobilization of the jaw as the disease proceeds, resulting in total jaw paralysis over time. Oral submucous fibrosis is a chronic, debilitating disease characterized by inflammation and progressive fibrosis of the submucosal tissues lamina propria and deeper connective tissues. Epidemiology oral submucous fibrosis osf, first described in the early 1950s, is a potentially malignant disease predominantly seen in people of asian descent. Oral submucous fibrosis is an insidious chronic disease affecting any part of the oral cavity and sometimes the pharynx, occasionally preceded by vesicle formation, always associated with fibrous bands and juxtaepithelial inflammatory reaction followed by a fibroelastic change of lamina propria with epithelial atrophy leading to stiffness of oral mucosa, trismus and inability to eat. The areca nut an is the primary ingredient in various bq products, and the international agency for research on cancer iarc has classified the an as a group i human carcinogen based on findings indicating that it is associated with an elevated risk for oral potentially malignant disorders opmds, such as leukoplakia, oral submucous fibrosis, erythroplakia, and lichen planus and cancers of. It is characterized by the progressive fibrosis of the submucosal tissue. The who definition for an oral precancerous condition a generalized. The symptoms and signs depend on the progression of the lesions and number of affected sites. In patients with oral submucous fibrosis, the risk of developing oral carcinoma is 7.
A digital manual for the early diagnosis of oral neoplasia. Diagnostic aids for detection of oral precancerous conditions. Oral submucous fibrosis 31 in europe or north america. Efficacy of turmeric in reducing burning sensation in oral. The area of dentistry devoted to the compilation and study of the patients dental history and a detailed clinical examination of the oral tissues and radiographs to assess oral health, with the object of developing a treatment plan to restore tooth structure and proper occlusion and to promote healing and better oral health. Oral submucous fibrosis affects the oral tissue of the buccal mucosa, lips, soft palate, and occasionally the pharynx. This causes blanching of the mucosa and can affect speech by res tricting tongue and soft palate movements. Oral submucous fibrosis osf is a chronic, progressive, scarring disease, that.
The disease is predominantly seen in india, bangladesh, sri lanka, pakistan, taiwan, southern china, polynesia and micronesia. Oral submucous fibrosis osf is a high risk precancerous condition characterized by. Clinicopathological study of 170 cases of oral submucous. Oral submucous fibrosis, a clinically benign but potentially. This condition was described first by schwartz 1952. The tissue is symmetrically affected and becomes progressively firm and pale. The underlying muscles of mastication may be affected resulting in trismus and disability. Osmf still remains a dilemma to the clinicians due to elusive pathogenesis and less welldefined classification systems. Autogenous buccal fat pad in the treatment of oral.
A study on orientation of collagen fibres in oral submucous. Pindborg and sirsat3 gave definition for osmf as as an insidious chronic disease affecting any part of the oral cavity and sometimes pharynx, although occasionally preceded by. Millions of individuals are affected, especially in south and south east asian countries. Oral diagnosis definition of oral diagnosis by medical. Oral submucous fibrosis osf is a potentially malignant disorder carrying the highest risk of malignant transformation among the oral premalignant lesions. Oral submucous fibrosis osf is a premalignant disorder associated with the chewing of areca nut betel nut. Oral submucous fibrosis a study although many studies proved that main causative agent is areca nut. Oral submucous fibrosis a disease with malignant potential report. In osmf, curcumin reduces the micronuclei formation in exfoliated mucosal cells. Pdf oral submucous fibrosis osmf is an insidious, chronic, complex, crippling, debilitating, irreversible, progressive, scarring, potentially. Proinflammatory cytokine levels in oral lichen planus, oral. The who definition for an oral precancerous original article abstract introduction. Index definition history keywords pathogenesis clinical features laboratory findings classification treatment 3.
Oral submucous fibrosis osmf, a precancerous condition of the oral cavity, has been studied by a number of workers in the field. The available epidemiological data showed a clearcut geographical and ethnic predisposition, which suggested that certain customshabits prevalent among the population groups in southeast asia might be possible etiological factors. Oral submucous fibrosis osf is a form of pathological fibrosis affecting the oral mucosa and contiguous areas of the upper aerodigestive tract, having a relentless course of progression 63. Nov 24, 2012 oral submucous fibrosis osf is an extremely discomforting oral condition that is marked by the development of painful lesions inside the mouth that refuse to go away on their own. Oral submucous fibrosis osf is a premalignant condition mainly associated with the practice of chewing betel quid containing areca nut, a habit common among south asian people. Due to its high morbidity and high malignant transformation rate.
Oral submucous fibrosis current concepts in etiopathogenesis. Immunohistochemical study of matrix metalloproteinase1 mmp. A wide range of treatment modalities have been proposed for osf, but none have proved curative or reduced the morbidity significantly. Oral submucous fibrosis is widely prevalent in all age groups and across all socioeconomic strata in india. It is characterized by inflammation, increased deposition of submucosal collagen and formation of fibrotic bands in the oral and paraoral tissues, which increasingly limit. Concomitant association of oral submucous fibrosis and oral. Proposed clinical definition for oral submucous fibrosis. Definition it is an insidious chronic disease affecting any part of the oral cavity and sometimes the pharynx. Oral sub mucous fibrosis osmf is a precancerous condition with a high malignant potential, which is often overlooked during the management of this condition. The available epidemiological data showeda clearcutgeographicaland.